?-Mangostin

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?-Mangostin

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Cat No: 29108

α-Mangostin is a xanthone that has been found in G. mangostana and has diverse biological activities.{39821,39824,56091,56092,56093} It inhibits fatty acid synthase and HIV-1 protease (IC50s = 5.54 and 5.12 μM, respectively).{39824,56091} α-Mangostin ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one

Correlated keywords:

1596362-31-0 Garcinia FA HIV1 Staphylococcus PGE 2 lipopolysaccharide RAW264.7 22 Rv1 DU 145 PC 3 NSC139154 NSC27593 7-O-Methyl-4-desprenylcostatin 7-O -Methyl-?-mangostin

Product Overview:
α-Mangostin is a xanthone that has been found in G. mangostana and has diverse biological activities.{39821,39824,56091,56092,56093} It inhibits fatty acid synthase and HIV-1 protease (IC50s = 5.54 and 5.12 μM, respectively).{39824,56091} α-Mangostin is active against methicillin-sensitive and -resistant S. aureus strains (MICs = 1.57-12.5 μg/ml).{39821} It inhibits nitric oxide and prostaglandin E2 (PGE2; Item No. 14010) production in LPS-stimulated RAW 264.7 cells (IC50s = 12.4 and 11.08 μM, respectively).{56092} α-Mangostin is an agonist of stimulator of interferon genes (STING) that binds to the C-terminal domain of STING (H232 variant) with a Kd value of 137 μM and induces expression of an IFN-β-luciferase reporter in HEK293T cells transfected with human STING (H232 variant) to a greater extent than cells expressing murine STING or human STING (R232 variant) when used at a concentration of 25 μM.{56103} α-Mangostin (20 mg/kg) prevents carrageenan-induced paw edema in mice. It decreases the viability of LNCaP, 22Rv1, DU145, and PC3 prostate cancer cells in vitro (IC50s = 5.9, 6.9, 22.5, and 12.7 μM, respectively) and reduces tumor growth in a 22Rv1 mouse xenograft model when administered at a dose of 100 mg/kg.{56093}

Size	10 mg
Shipping	dry ice
CAS Number	01/11/6147 00:00
Molecular Formula	C₂₄H₂₆O₆
SMILES	OC1=C2C(OC(C=C(O)C(OC)=C3C/C=C(C)/C)=C3C2=O)=CC(O)=C1C/C=C(C)/C
Molecular Weight	410,5
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2907.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.