Daunorubicin-13C-d3

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Daunorubicin-¹³C-d₃

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Cat No: 29101

Daunorubicin-13C-d3 is intended for use as an internal standard for the quantification of daunorubicin (Item No. 14159) by GC- or LC-MS. Daunorubicin is an antitumor antibiotic.{22542} At 0.2-1 μM, daunorubicin induces apoptosis in mature monocytic U9...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

8S-acetyl-10S-[(3-amino-2,3,6-trideoxy-?-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-(methoxy-13C-d3)-5,12-naphthacenedione

Correlated keywords:

20830-81-3 NDC 0082-4155 00824155 NDC00824155 NDC0082 RP13057 RP-13057 GCMS LCMS carbon-13 carbon13 C d-3 Ondena HL60 CD34+KG1a CD34+KG1 CD34+HEL CD34KG1a CD34KG1 CD34HEL CD34 MEKK1SEK1JNK MEKK1SEK1 SEK1JNK AP1 anti-tumor deuterated deuterium

Product Overview:
Daunorubicin-13C-d3 is intended for use as an internal standard for the quantification of daunorubicin (Item No. 14159) by GC- or LC-MS. Daunorubicin is an antitumor antibiotic.{22542} At 0.2-1 μM, daunorubicin induces apoptosis in mature monocytic U937 and myelocytic HL-60 acute myeloid leukemia (AML) cells. However, immature AML cells (CD34+-KG1a, -KG1, or -HEL cells) appear resistant to apoptosis at similar concentrations.{22542} In mature AML cells, daunorubicin has been shown to trigger a reactive oxygen species-dependent sphingomyelin-ceramide pathway that activates the MEKK1-SEK1-JNK cascade leading to enhanced DNA binding activity of the transcription factor AP-1.{5396,22542}

Size	250 µg
Shipping	dry ice
Molecular Formula	C₂₆[¹³C]H₂₆D₃NO₁₀
SMILES	O=C1C2=C(C(O)=C([C@@H](O[C@@]3([H])C[C@H](N)[C@H](O)[C@H](C)O3)C[C@@](C(C)=O)(O)C4)C4=C2O)C(C5=C(O[13C]([2H])([2H])[2H])C=CC=C51)=O
Molecular Weight	531,5
Formulation	A solid
Purity	≥99% deuterated forms (d1-d3)
Custom Code	3822.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.