Forsythoside B

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Forsythoside B

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Cat No: 29051

Biochemicals - Ion Channel Modulation

Forsythoside B is phenylpropanoid glycoside that has been found in M. alysson and has diverse biological activities.{48654,48655,48656,48658,48657} It scavenges PTIO (Item No. 14982), ABTS (Item No. 27317), O2-, and 2,2-diphenyl-1-picrylhydrazyl (DPPH...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-(3,4-dihydroxyphenyl)ethyl O-D-apio-?-D-furanosyl-(1?6)-O-[6-deoxy-?-L-mannopyranosyl-(1?3)]-?-D-glucopyranoside, 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]

Correlated keywords:

phenyl propanoid Marrubium bm MSC amino ethoxy diphenyl TRPV 3 HEK 293 TNF? IL6 IL10 TREM1

Product Overview:
Forsythoside B is phenylpropanoid glycoside that has been found in M. alysson and has diverse biological activities.{48654,48655,48656,48658,48657} It scavenges PTIO (Item No. 14982), ABTS (Item No. 27317), O2-, and 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in cell-free assays (IC50s = 125.5, 14, 262.6, and 8.7 μM, respectively).{48655} Forsythoside B (10-100 μg/ml) reduces hydrogen peroxide-induced cytotoxicity in bone marrow-derived mesenchymal stem cells (bmMSCs). It inhibits 2-aminoethoxydiphenyl borate-induced activation of transient receptor potential vanilloid 3 (TRPV3; IC50 = 6.7 μM in HEK293 cells expressing the human receptor) and reduces carvacrol-induced scratching behavior in mice.{48656} Forsythoside B (40 mg/kg) reduces serum levels of TNF-α, IL-6, IL-10, endotoxin, and triggering receptor expressed on myeloid cells 1 (TREM-1) and increases survival in a rat model of cecal ligation and puncture-induced sepsis.{48658} It also reduces infarct size and brain edema in a rat model of cerebral ischemia and reperfusion injury induced by middle cerebral artery occlusion.{48657}

Size	5 mg
Shipping	dry ice
CAS Number	81525-13-5
Molecular Formula	C₃₄H₄₄O₁₉
SMILES	OC(C=C1)=C(O)C=C1CCO[C@@H]2O[C@H](CO[C@H]3[C@H](O)[C@](CO)(O)CO3)[C@@H](OC(/C=C/C4=CC=C(O)C(O)=C4)=O)[C@H](O[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)[C@H]2O
Molecular Weight	756,7
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2938.90
UNSPSC code	12352100

Technical File

MSDS

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.