Nedaplatin

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Nedaplatin

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Cat No: 29001

Biochemicals - More Biochemicals

Nedaplatin is a derivative of cisplatin (Item No. 13119) with anticancer activity.{48686} Nedaplatin undergoes spontaneous hydrolysis to form platinum complexes that cross-link DNA resulting in apoptosis and cell death.{48683,48684} It inhibits the gr...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(SP-4-3)-diammine[2-(hydroxy-?O)acetato(2-)-?O]-platinum

Correlated keywords:

anti cancer crosslink NUGC4 KSE1 G 2 1 HNC3 nephro toxicity 254-S 254S CGDP NDP NED TIN hydroxy-acetic acid hydroxyacetic acid NSC375101 Aqupla S254 cis-diammine(glycolato)platinum

Product Overview:
Nedaplatin is a derivative of cisplatin (Item No. 13119) with anticancer activity.{48686} Nedaplatin undergoes spontaneous hydrolysis to form platinum complexes that cross-link DNA resulting in apoptosis and cell death.{48683,48684} It inhibits the growth of human NUGC-4 gastric and KSE-1 esophageal squamous carcinoma cells (IC50s = 4.6 and 3.4 μM, respectively) and inhibits S to G2 and G2/M to G1 cell cycle progression.{48685} Nedaplatin (44 mg/kg) decreases tumor volume and increases survival in a Lewis lung carcinoma syngeneic mouse model.{48686} Nedaplatin (40 mg/kg) also decreases tumor volume in an HNC-3 head and neck cancer mouse xenograft model.{48687} It exhibits reduced nephrotoxicity in rats compared with cisplatin.{48684}

Size	25 mg
Shipping	dry ice
CAS Number	95734-82-0
Molecular Formula	C₂H₈N₂O₃Pt
SMILES	[NH3][Pt+2]([O-]C1=O)([O-]C1)[NH3]
Molecular Weight	303,2
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2843.90
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.