smgGDS-607 Monoclonal Antibody

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Cat No: 28945

SmgGDS is a chaperone protein and guanine nucleotide exchange factor encoded by RAP1GDS1 that regulates the prenylation and trafficking of small GTPases and has a role in oncogenesis.{54803,59352,54804} Alternative splicing of the RAP1GDS1 pre-mRNA pr...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

?smgGDS607 smgGDS558 GDS1

Product Overview:
SmgGDS is a chaperone protein and guanine nucleotide exchange factor encoded by RAP1GDS1 that regulates the prenylation and trafficking of small GTPases and has a role in oncogenesis.{54803,59352,54804} Alternative splicing of the RAP1GDS1 pre-mRNA produces a full-length isoform, smgGDS-607, and a short isoform, smgGDS-558.{54803} SmgGDS-607 is composed of 607 residues and contains an N-terminal nuclear export sequence and multiple armadillo repeats, which are essential for binding to small GTPases that contain a C-terminal polybasic region.{54803,59352,54805} It is expressed in a variety of tissues and cancer cell lines.{59352} SmgGDS-607 binds to newly synthesized, preprenylated small GTPases and traffics them to prenyltransferases (PTases), which catalyze their prenylation, a process that is critical for the membrane localization and subsequent activation of small GTPases.{59352,54804} An elevated ratio of smgGDS-607 to smgGDS-558 has been observed in cancer cell lines and is associated with reduced survival in patients with breast cancer.{59352} Cayman's smgGDS-607 Monoclonal Antibody can be used for ELISA, immunohistochemistry (IHC), and Western blot (WB) applications. The antibody recognizes a unique region of smgGDS-607 that is not present in smgGDS-558, specifically detecting smgGDS-607 at ~60 kDa from human and African green monkey samples.

Size	500 µg
Shipping	dry ice
Host	Mouse
Antigen	Peptide between residues 122-170 of human smgGDS-607
Clone	4D6
Isotype	IgG1
Application(s)	ELISA, IHC, WB
Formulation	500 µg of protein G-purified monoclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.