Rose Bengal (sodium salt)

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Cat No: 28829

Rose bengal is a xanthene dye, fluorescein derivative, and photosensitizer.{46508,46509} It exhibits absorption/emission maxima of 548/567 nm, respectively.{22804} Rose bengal binds to S. aureus cells and decreases survival of photoirradiated S. aureu...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4,5,6,7-tetrachloro-3?,6?-dihydroxy-2?,4?,5?,7?-tetraiodo-spiro[isobenzofuran-1(3H),9?-[9H]xanthen]-3-one, disodium salt

Correlated keywords:

15816-66-7 18265-56-0 51799-27-0 55711-73-4 74198-03-1 157367-41-4 192930-93-1 198831-91-3 337360-08-4 410097-66-4 677032-84-7 861686-24-0 951248-21-8 1245731-28-5 1350479-68-3 1622253-48-8 4159-77-7 extra Staphylococcus staph P-450 CYP3A5 CYP3A UGT-1A6 UGT1A-6

Product Overview:
Rose bengal is a xanthene dye, fluorescein derivative, and photosensitizer.{46508,46509} It exhibits absorption/emission maxima of 548/567 nm, respectively.{22804} Rose bengal binds to S. aureus cells and decreases survival of photoirradiated S. aureus to 0.012% when used at a concentration of 1 μM.{46508} It generates singlet oxygen when exposed to photoirradiation in cell-free assays and induces potassium ion leakage from S. aureus and bovine erythrocytes in the presence of photoirradiation. Rose bengal inhibits the cytochrome P450 (CYP) isoform CYP3A4/5 and the UDP-glucuronosyltransferase (UGT) isoform UGT1A6 in human liver microsomes in a light-dependent manner, with IC50 values of 0.072 and 0.035 μM, respectively, in yellow light, 3.1 and 4.2 μM, respectively, in ambient light, and 3 and 4.2 μM, respectively, in the dark.{46510} It has been used for staining of live cells, but exhibits both intrinsic and phototoxicity.{46509}

Size	25 g
Shipping	dry ice
CAS Number	632-69-9
Molecular Formula	C₂₀H₂Cl₄I₄O₅ • 2Na
SMILES	IC1=CC2=C(C(I)=C1[O-])OC3=C(I)C([O-])=C(I)C=C3C24C(C(Cl)=C(Cl)C(Cl)=C5Cl)=C5C(O4)=O.[Na+].[Na+]
Molecular Weight	1017,6
Formulation	A crystalline solid
Purity	≥90%
Custom Code	2932.20
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.