17R(18S)-EpETE

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17R(18S)-EpETE

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Cat No: 28630

Biochemicals - Ion Channel Modulation

17R(18S)-EpETE is an oxylipin and a cytochrome P450 metabolite of eicosapentaenoic acid (EPA; Item Nos. 90110
90110.1
21908).{11951,9825} 17R(18S)-EpETE is an activator of large-conductance calcium-activated potassium (KCa1.1/BK) channels, increas...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

16-[(2R,3S)-3-ethyl-2-oxiranyl]-5Z,8Z,11Z,14Z-hexadecatetraenoic acid

Correlated keywords:

17R,18S-EpETA 17R,18S-EETeTr 17R18S P-450 BK-Ca VSMC NRCM

Product Overview:
17R(18S)-EpETE is an oxylipin and a cytochrome P450 metabolite of eicosapentaenoic acid (EPA; Item Nos. 90110
90110.1
21908).{11951,9825} 17R(18S)-EpETE is an activator of large-conductance calcium-activated potassium (KCa1.1/BK) channels, increasing the potassium current amplitude by 15-fold in isolated rat cerebral artery vascular smooth muscle cells (VSMCs) at +60 mV when used at a concentration of 50 nM.{9825} It has negative chronotropic effects in isolated neonatal rat cardiomyocytes (NRCMs; EC50 = ~1-2 nM) and prevents calcium-induced increases in the spontaneous beating of NRCMs.{19905,18672}

Size	25 µg
Shipping	dry ice
CAS Number	725246-18-4
Molecular Formula	C₂₀H₃₀O₃
SMILES	CC[C@H]1[C@H](O1)C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O
Molecular Weight	318,5
Formulation	A solution in ethanol
Purity	≥98%
Custom Code	2916.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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