Corynoxine (hydrochloride)

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Cat No: 28496

Biochemicals - Natural Products

Corynoxine is an indole alkaloid that has been found in U. macrophylla and has neuroprotective activity.{45601,45602} It increases levels of the autophagy marker LC3-II in Neuro2a and SH-SY5Y neuronal cells when used at concentrations ranging from 6.2...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(?E,1?S,6?S,7?S,8?aS)-6?-ethyl-1,2,2?,3?,6?,7?,8?,8?a-octahydro-?-(methoxymethylene)-2-oxo-spiro[3H-indole-3,1'(5?H)-indolizine]-7?-acetic acid, methyl ester, monohydrochloride

Correlated keywords:

6877-32-3 28645-82-1 Corynoxan carboxylic Ulmus neuro-protective LC3II Neuro-2a SHSY5Y A-53T A53-T ?synuclein PC-12

Product Overview:
Corynoxine is an indole alkaloid that has been found in U. macrophylla and has neuroprotective activity.{45601,45602} It increases levels of the autophagy marker LC3-II in Neuro2a and SH-SY5Y neuronal cells when used at concentrations ranging from 6.25 to 25 µM.{45601} Corynoxine (25 µM) increases degradation of wild-type and A53T mutant α-synuclein, a major component of Lewy bodies in the brain of Parkinson’s disease patients, in PC12 cells, an effect that can be reversed by the autophagy inhibitors 3-methyladenine (Item No. 13242) and chloroquine (Item No. 14194). It reduces increases in methamphetamine-induced locomotor activity in rats when administered at doses of 30 and 100 mg/kg.{45602}

Size	500 µg
Shipping	dry ice
Molecular Formula	C₂₂H₂₈N₂O₄ • HCl
SMILES	CO/C=C(C(OC)=O)\[C@@H]1[C@H](CC)CN2[C@@]([C@@]3(C(C=CC=C4)=C4NC3=O)CC2)([H])C1.Cl
Molecular Weight	420,9
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.79
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.