Norcantharidin

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Norcantharidin

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Cat No: 28457

Biochemicals - Small Molecule Inhibitors

Norcantharidin is a demethylated form of the protein phosphatase 1 (PP1) and PP2A inhibitor cantharidin (Item No. 14589) and a PP1 and PP2A inhibitor (IC50s = 9 and 3 µM, respectively).{46995,46996} It induces cell cycle arrest at the G2/M phase and a...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(3aR,4S,7R,7aS)-rel-hexahydro-4,7-epoxyisobenzofuran-1,3-dione

Correlated keywords:

167933-28-0 201815-15-8 204204-47-7 433956-00-4 1446101-67-2 1474031-41-8 NSC59023 Demethyl cantharidin Isocantharidin PP 1 2A G 2 HepG 2 Hep G2 3B Huh 7 GBCSD

Product Overview:
Norcantharidin is a demethylated form of the protein phosphatase 1 (PP1) and PP2A inhibitor cantharidin (Item No. 14589) and a PP1 and PP2A inhibitor (IC50s = 9 and 3 µM, respectively).{46995,46996} It induces cell cycle arrest at the G2/M phase and apoptosis in HepG2, Hep3B, and Huh7 human hepatoma cell lines when used at a concentration of 5 µg/ml.{46996} Norcantharidin (500-5,000 µg/ml) reduces angiogenesis in a chick chorioallantoic membrane assay.{46997} It inhibits growth in a panel of nine human cancer cell lines, including breast, lung, skin, and glioblastoma cancer cells, with GI50 values ranging from 30 to 64 µM.{46995} Norcantharidin (28 mg/kg, i.p.) reduces tumor growth in a GBC-SD mouse xenograft model.

Size	1 g
Shipping	dry ice
CAS Number	29745-04-8
Molecular Formula	C₈H₈O₄
SMILES	O=C1OC([C@@]2([H])[C@@H]3CC[C@@H](O3)[C@]21[H])=O
Molecular Weight	168,1
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2932.99
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.