Piclidenoson

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Piclidenoson

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Cat No: 28445

Biochemicals - Receptor Pharmacology

Piclidenoson is an adenosine A3 receptor agonist (Ki = 1.7 nM).{52557} It is selective for adenosine A3 over A1 and A2 receptors (Kis = 55.3 and 3,099 nM, respectively). In vivo, piclidenoson (100 µg/kg) reduces wall thickening in a rabbit model of is...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1-deoxy-1-[6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-N-methyl-?-D-ribofuranuronamide

Correlated keywords:

215462-30-9 IBMECA CF-101 C-F101

Product Overview:
Piclidenoson is an adenosine A3 receptor agonist (Ki = 1.7 nM).{52557} It is selective for adenosine A3 over A1 and A2 receptors (Kis = 55.3 and 3,099 nM, respectively). In vivo, piclidenoson (100 µg/kg) reduces wall thickening in a rabbit model of ischemia-reperfusion injury induced by coronary artery occlusion, an effect that can be reversed by the adenosine receptor antagonist 8-p-sulfophenyl theophylline.{52556} It reduces hepatocellular tumor growth, liver inflammation, and neuropathy in a rat model of bone-residing breast cancer and decreases the number of lung metastases in a model of metastatic murine melanoma.{52557} Piclidenoson (1 and 3 mg/kg) also reduces colonic inflammatory cell infiltration and damage in a mouse model of colitis induced by dextran sulfate (DSS; Item No. 23250) and in IL-10-/- mice.{52558}

Size	1 mg
Shipping	dry ice
CAS Number	152918-18-8
Molecular Formula	C₁₈H₁₉IN₆O₄
SMILES	[H][C@]1(O[C@H](C(NC)=O)[C@@H](O)[C@H]1O)N2C=NC3=C(NCC4=CC=CC(I)=C4)N=CN=C32
Molecular Weight	510,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2932.19
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.