PSI (trifluoroacetate salt)

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Cat No: 28382

Biochemicals - Small Molecule Inhibitors

PSI is a synthetic peptide proteasome inhibitor.{60338,60339,60342} It inhibits the acidic and neutral chymotrypsin-like activities of the 20S proteasome (IC50s = 0.25 and 6.5 µM, respectively).{60342} PSI is cytotoxic to HL-60, KG-1a, RWLeu-4, AR230,...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

tert-butyl (S)-4-((2S,3S)-2-(((benzyloxy)carbonyl)amino)-3-methylpentanamido)-5-(((S)-1-(((S)-4-methyl-1-oxopentan-2-yl)amino)-1-oxopropan-2-yl)amino)-5-oxopentanoate, trifluoroacetate salt

Correlated keywords:

916041-38-8 158442-41-2 benzyloxycarbonyl-Ile-Glu(O-tert-butyl)-Ala-leucinal N-benzyloxycarbonyl-Ile-Glu-(O-t-Bu)-Ala-leucinal Z-IE(Ot-Bu)AL-CHO HL60 HL60 KG1a RWLeu4 AR-230 K-562 BAEC HUVEC HT-4

Product Overview:
PSI is a synthetic peptide proteasome inhibitor.{60338,60339,60342} It inhibits the acidic and neutral chymotrypsin-like activities of the 20S proteasome (IC50s = 0.25 and 6.5 µM, respectively).{60342} PSI is cytotoxic to HL-60, KG-1a, RWLeu-4, AR230, and K562 human leukemia cells (IC50s = 4.9, 17.5, 7.8, 7.3, and 10 nM, respectively).{60340} It selectively induces apoptosis in subconfluent bovine aortic endothelial cells (BAECs) and human umbilical vein endothelial cells (HUVECs; EC50s = 24 and 7 nM, respectively) over confluent BAECs and HUVECs (EC50s = 8,150 and 7,830 nM, respectively).{60341} PSI induces accumulation of ubiquitin-protein conjugates in HT4 mouse neuronal cells.{60343}

Size	1 mg
Shipping	dry ice
Molecular Formula	C₃₂H₅₀N₄O₈ • XCF₃COOH
SMILES	O=C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(OC(C)(C)C)=O)C(N[C@@H](C)C(N[C@H](C=O)CC(C)C)=O)=O)=O)OCC1=CC=CC=C1.OC(C(F)(F)F)=O
Molecular Weight	618,8
Formulation	A solid
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.