?-Methylamino-L-Alanine (hydroch

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?-Methylamino-L-Alanine (hydrochloride)

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Cat No: 23287

β-Methylamino-L-alanine (BMAA) is a neurotoxic non-proteinogenic amino acid that has been found in cyanobacteria.{59025,59026} It is cytotoxic to mouse primary cortical neurons when used at a concentration of 3 mM in the presence of bicarbonate, an ef...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-(methylamino)-L-alanine, monohydrochloride

Correlated keywords:

15920-93-1 HCl cyanotoxin cyano toxin MK801 nonproteinogenic mGluR-5 intra cerebro ventricular

Product Overview:
β-Methylamino-L-alanine (BMAA) is a neurotoxic non-proteinogenic amino acid that has been found in cyanobacteria.{59025,59026} It is cytotoxic to mouse primary cortical neurons when used at a concentration of 3 mM in the presence of bicarbonate, an effect that can be blocked by the NMDA receptor antagonist MK-801 or the mGluR5 receptor antagonist MPEP (Item No. 14536).{59027} BMAA (3 mM) stimulates release of glutamate and induces oxidative stress in the same cells.{59028} It also enhances neuronal cell death induced by amyloid-β (25-35) in mouse primary cortical neurons when used at a concentration of 0.1 mM.{59027} Intracerebroventricular administration of BMAA (500 µg/animal) induces wet-dog shakes, rigidity, and clonic convulsions in rats.{59029} It induces parkinsonism in cynomolgus monkeys.{59030} BMAA has been found in commercial seafood.{59031}

Size	5 mg
Shipping	dry ice
CAS Number	16012-55-8
Molecular Formula	C₄H₁₀N₂O₂ • HCl
SMILES	N[C@H](C(O)=O)CNC.Cl
Molecular Weight	154,6
Formulation	A solid
Purity	≥95%
Custom Code	2921.29
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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