Donecopride (fumarate hydrate)

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Cat No: 16962

Biochemicals - Receptor Pharmacology

Donecopride is a partial agonist of the serotonin (5-HT) receptor subtype 5-HT4E (Ki = 8.5 nM) and an inhibitor of acetylcholinesterase (AChE; IC50 = 16 nM).{27327} It is selective for AChE over butyrylcholinesterase (BChE; IC50 = 3,530 nM) but does b...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-(cyclohexylmethyl)piperidin-4-yl)propan-1-one fumarate, hydrate

Correlated keywords:

1624996-89-9 1624996-90-2 MR-31147 5HT4 5HT 4E 2B 5HT4E 5HT2B sAPP? COS7 A?-42 sA?-42

Product Overview:
Donecopride is a partial agonist of the serotonin (5-HT) receptor subtype 5-HT4E (Ki = 8.5 nM) and an inhibitor of acetylcholinesterase (AChE; IC50 = 16 nM).{27327} It is selective for AChE over butyrylcholinesterase (BChE; IC50 = 3,530 nM) but does bind to 5-HT2B and sigma-2 (σ2) receptors (Ki = 1.6 nM for both) in a panel of 42 neurotransmitter receptors and transporters. Donecopride induces release of soluble amyloid precursor protein-α (sAPP-α) in COS-7 cells transiently expressing 5-HT4 with an EC50 value of 11.3 nM. Oral administration of donecopride (1 mg/kg) reduces brain soluble and insoluble amyloid-β (1-42) (Aβ42; Item No. 20574) levels and increases the time spent exploring the novel object in the novel object recognition (NOR) test in the 5XFAD transgenic mouse model of Alzheimer's disease. Donecopride (3 mg/kg, p.o.) prevents a reduction in spontaneous alternation behavior induced by intracerebroventricular administration of soluble Aβ42 (sAβ42) in the Y-maze in mice.{53785}

Size	1 mg
Shipping	dry ice
Molecular Formula	C₂₂H₃₃ClN₂O₂ • C₄H₄O₄ [XH₂O]
SMILES	NC1=CC(OC)=C(C(CCC2CCN(CC3CCCCC3)CC2)=O)C=C1Cl.OC(/C=C/C(O)=O)=O.O
Molecular Weight	509
Formulation	A solid
Purity	≥95%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.