15-deoxy-?12,14-Prostaglandin J2

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15-deoxy-?^12,14-Prostaglandin J₂-2-glycerol ester

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Cat No: 10010132

Biochemicals - Lipids

15-deoxy-Δ12,14-Prostaglandin J2-2-glycerol ester (15-deoxy-Δ12,14-PGJ2-2-glycerol ester) is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 value of 2 µM in a murine chimera system.{1428,1424}...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

11-oxo-prosta-5Z,9,12E,14E-tetraen-1-oic acid, 2-glycerol ester

Correlated keywords:

PPARgamma PPAR.gamma. PPARg PGD2 PGJ2 lipolysis prostaglandins adipocyte endocannabinoid metabolism diabetes obesity nuclear receptors COX-2 COX2 2-AG 2AG cannabinoids cbs synthetic

Product Overview:
15-deoxy-Δ12,14-Prostaglandin J2-2-glycerol ester (15-deoxy-Δ12,14-PGJ2-2-glycerol ester) is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 value of 2 µM in a murine chimera system.{1428,1424} 15-deoxy-Δ12,14-PGJ2-2-glycerol ester is more potent than PGD2, Δ12-PGJ2, and PGJ2 in stimulating lipogenesis in C3H10T1/2 cells. The EC50 value for induction of adipocyte differentiation in cultured fibroblasts is 7 µM.{1428} PG glycerol esters are generated by the action of cyclooxygenase-2 on the endocannabinoid 2-arachidonyl glycerol.{11045} The biosynthesis of PGH, PGD, PGE, PGF, and TXA-2-glyceryl ester compounds have all been documented. While the stability and metabolism of these PG products has been investigated,{10555} little is known about their intrinsic biological activity.

Size	100 µg
Shipping	dry ice
Molecular Formula	C₂₃H₃₄O₅
SMILES	O=C1C=C[C@H](C/C=C\CCCC(OC(CO)CO)=O)/C1=C\C=C\CCCCC
Molecular Weight	390,5
Formulation	A solution in ethanol
Purity	≥98% (isomer mixture)
Custom Code	2937.50
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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