HDAC5 (human, recombinant)

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Cat No: 10009379

Proteins - Enzymes

Histone deacetylases (HDACs) catalyze the deacetylation of core histones, resulting in tightening of nucleosomal integrity, restriction of the access of transcription factors, and suppression of transcription. HDACs also play an important role in medi...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

HDAC 5 histones deacetylases enzymes HDACs catalyzes deacetylation nucleosomal nucleosomes transcription factors mediating mediators extranuclear receptors co-repressor complexes regulatory pathways E2F TFIIE TFIIF NF-.kappa.B NF-kappaB NF-kB p300 Stat3 p53 retinoblastoma Rb proteins Class IIa yeast Hda 1 catalytic domains amino acids N-terminal N-terminus nucleus cytoplasm cells chromatin structures development differentiation programmed death apoptosis angiogenesis inflammation dysregulation pathogenesis diseases cancers C-terminal C-terminus his-tagged baculovirus Sf9 active

Product Overview:
Histone deacetylases (HDACs) catalyze the deacetylation of core histones, resulting in tightening of nucleosomal integrity, restriction of the access of transcription factors, and suppression of transcription. HDACs also play an important role in mediating nuclear receptor functions by forming co-repressor complexes with nuclear receptors in the absence of ligands. They are also involved in mediating other transcription regulatory pathways by associating with transcription factors, such as E2F, TFIIE, TFIIF, NF-κB, p300, Stat3, p53, and the retinoblastoma (Rb) protein.{14467} HDAC5 is a Class IIa HDAC which is homologous to yeast Hda 1 and is larger in size than the other two classes of HDACs.{14467,14468} Class IIa HDACs contain a highly conserved C-terminal deacetylase catalytic domain (~420 amino acids) and an N-terminal domain with no similarity to HDACs in other classes. Class IIa HDACs can shuttle between the nucleus and cytoplasm, suggesting potential extranuclear functions by regulating the acetylation status of non-histone substrates. By modifying chromatin structure and other non-histone proteins, HDACs play important roles in controlling complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation. Considering these major roles, it is conceivable that dysregulation of HDACs and subsequent imbalance of acetylation and deacetylation may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.{14468}

Size	1 ea
Shipping	dry ice
Molecular Weight	51
Formulation	45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 225 imidazole, and 10% glycerol
Purity	≥90%
Custom Code	3507.90
UNSPSC code	12352202

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.