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Leukotriene D4-d5 (LTD4-d5) is intended for use as an internal standard for the quantification of LTD4 (Item No. 20310) by GC- or LC-MS. LTD4 is an active metabolite of LTC4 (Item Nos. 20210 | 10007241) and a constituent of slow-reacting substance of anaphylaxis (SRS-A).{541,589} It is formed via metabolism of LTC4 by ?-glutamyl transpeptidase. Like LTC4, LTD4 (0.01-0.1 pM) induces contractions in isolated guinea pig parenchymal strips and tracheal spirals.{396} In vivo, LTD4 increases insufflation pressure, a marker of bronchoconstriction, in anesthetized guinea pigs by 100% when administered at a dose of 89 pmol per animal.{4157} It also increases vascular permeability in guinea pig skin when administered intradermally at a dose of 0.1 pmol per animal.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µg, 25 µg, 50 µg |
|---|---|
| Shipping | dry ice |
| CAS number | 1240398-17-7 |
| Molecular formula | C25H35D5N2O6S |
| Smiles | N[C@H](C(NCC(O)=O)=O)CS[C@@H]([C@@H](O)CCCC(O)=O)/C=C/C=C/C=CC/C=CCCCC([2H])([2H])C([2H])([2H])[2H], N[C@H](C(NCC(O)=O)=O)CS[C@@H]([C@@H](O)CCCC(O)=O)/C=C/C=C/C=CC/C=CCCCC([2H])([2H])C([2H])([2H])[2H], N[C@H](C(NCC(O)=O)=O)CS[C@@H]([C@@H](O)CCCC(O)=O)/C=C/C=C/C=CC/C=CCCCC([2H])([2H])C([2H])([2H])[2H] |
| Molecular weight | 501,7 |
| Custom code | 3822.19 |
| Formulation | A solution in ethanol |
| Purity | ≥99% deuterated forms (d1-d5) |
| UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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