Lactosylceramide and Ganglioside

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Lactosylceramide and Ganglioside G_M3 and G_D3 Mixture

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Cat No: 29361

Biochemicals - Lipids

Lactosylceramides (LacCers) are endogenous bioactive membrane sphingolipids. They have a role in phagocytosis, chemotaxis, and cell signaling.{41044} LacCer levels are correlated with insulin resistance, obesity, and hyperglycemia in diabetic mice and...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

LCMS GCMS G M3 D3 ceramide ganglioside Lac-Cer neuro-degeneration qualitative

Product Overview:
Lactosylceramides (LacCers) are endogenous bioactive membrane sphingolipids. They have a role in phagocytosis, chemotaxis, and cell signaling.{41044} LacCer levels are correlated with insulin resistance, obesity, and hyperglycemia in diabetic mice and LacCers enhance neurodegeneration in a mouse model of multiple sclerosis.{41045,27728} Sialogangliosides are membrane sphingolipids composed of sialic acid and oligosaccharide moieties with roles in cell proliferation, differentiation, adhesion, neuronal plasticity, intra- and intercellular signaling, and neurogenesis.{31218,25490,37782} They accumulate in a variety of lysosomal storage disorders including Sandhoff, Tay-Sachs, and Niemann-pick diseases.{40891,43703} Lactosylceramide and Ganglioside GM3 and GD3 Mixture contains LacCers, the monosialoganglioside GM3, and the disialoganglioside GD3. It is intended for use as a reference standard for the detection of LacCers, GM3, and GD3 in various sample types by TLC, LC-, or GC-MS. [Matreya, LLC. Catalog No. 1510]

Size	1 mL
Shipping	dry ice
Formulation	A solution in chloroform:methanol:water (2:1:0.1)
Custom Code	3822.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.