Morusin

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Morusin

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Cat No: 28857

Biochemicals - Lipids

Morusin is a prenylated flavonoid that has been found in M. alba and has diverse biological activities, including enzyme inhibitory, anti-inflammatory, and antiproliferative properties.{52095,52094,52093,59092} It inhibits the UDP-glucuronosyltransfer...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-(2,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-3-(3-methyl-2-buten-1-yl)-4H,8H-benzo[1,2-b:3,4-b?]dipyran-4-one

Correlated keywords:

Morus antiinflammatory anti-proliferative NSC649220 UGT-1 A-6 7 8 P-450 CYP-3 1 2 A-4 2 C-9 E-1 LTC-4 A-23187 MC-9 MCF7 MDAMB-231 453 MDA-MB231 MDAMB231 MDA-MB453 MDAMB453 TGF?1 MMP2 MMP9 U

Product Overview:
Morusin is a prenylated flavonoid that has been found in M. alba and has diverse biological activities, including enzyme inhibitory, anti-inflammatory, and antiproliferative properties.{52095,52094,52093,59092} It inhibits the UDP-glucuronosyltransferase (UGT) isoforms UGT1A6, UGT1A7, and UGT1A8 (IC50s = 4.23, 0.98, and 3 μM, respectively) and the cytochrome P450 (CYP) isoforms CYP3A4, CYP1A2, CYP2C9, and CYP2E1 (IC50s = 2.13, 1.27, 3.18, and 9.28 μM, respectively).{52095} Morusin (4 μM) inhibits histamine and leukotriene C4 (LTC4) production induced by A23187 (Item No. 11016) and phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in mouse MC/9 mast cells.{52094} It also inhibits the growth of MCF-7, MDA‑MB‑231, and MDA‑MB‑453 breast cancer cells (IC50s = 13.53, 10.84, and 11.99 μM, respectively).{52093} Morusin (12.5 mg/kg per day) decreases colonic tissue damage, TGF-β1 levels, and matrix metalloproteinase-2 (MMP-2) and MMP-9 activity in a rat model of TNBS-induced ulcerative colitis.{59092}

Size	5 mg
Shipping	dry ice
CAS Number	62596-29-6
Molecular Formula	C₂₅H₂₄O₆
SMILES	OC1=CC=C(C(OC2=C3C(O)=CC4=C2C=CC(C)(C)O4)=C(C/C=C(C)/C)C3=O)C(O)=C1
Molecular Weight	420,5
Formulation	A solid
Purity	≥98%
Custom Code	2907.19
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.