Cytarabine-13C3

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Cytarabine-¹³C₃

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Cat No: 28805

Cytarabine-13C3 (ara-C-13C3) is intended for use as an internal standard for the quantification of ara-C (Item No. 16069) by GC- or LC-MS. Ara-C is a nucleoside analog and prodrug form of the DNA polymerase inhibitor ara-CTP.{48724} It is triphosphory...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-amino-1-?-D-arabinofuranosyl-2(1H)-pyrimidinone-4,5,6-13C3

Correlated keywords:

GCMS LCMS araC anti viral NSC 63878 NSC63878 287459 NSC287459 U-19920A U19920A 19920 A Arabino furanosyl cytosine

Product Overview:
Cytarabine-13C3 (ara-C-13C3) is intended for use as an internal standard for the quantification of ara-C (Item No. 16069) by GC- or LC-MS. Ara-C is a nucleoside analog and prodrug form of the DNA polymerase inhibitor ara-CTP.{48724} It is triphosphorylated to ara-CTP by the successive actions of deoxycytidine kinase, deoxycytidylate kinase, and nucleoside diphosphate kinase.{48725} Ara-C inhibits proliferation of HL-60, ML-1, Raji, and Jurkat human leukemia cell lines with IC50 values of 37, 17, 16, and 72 nM, respectively.{48726} It induces cell cycle arrest at the G0/G1 phase in HL-60 cells when used at concentrations of 2.5 and 15 µM.{48724} Ara-C (75 mg/kg per day, i.p.) reduces tumor growth and increases tumor caspase-3 activity in an MOLM-13 mouse xenograft model.{48727} It also increases survival and reduces brain herpesvirus titers in infected rats when administered subcutaneously at doses of 80 and 320 mg/kg.{48728} Formulations containing ara-C have been used in the treatment of acute myeloid leukemia.

Size	1 mg
Shipping	dry ice
Molecular Formula	C₆[¹³C₃]H₁₃N₃O₅
SMILES	O[C@@H]1[C@H](N2C(N=[13C](N)[13CH]=[13CH]2)=O)O[C@H](CO)[C@H]1O
Molecular Weight	246,2
Formulation	A solid
Purity	≥95%
Custom Code	3822.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.