AMN082

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AMN082

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Cat No: 28779

Biochemicals - Receptor Pharmacology

AMN082 is an orally bioavailable allosteric agonist of metabotropic glutamate receptor 7 (mGluR7).{47688} It inhibits cAMP accumulation induced by forskolin in CHO cells expressing human mGluR7b (EC50 = 64 nM). AMN082 (10 μM) is selective for mGluR7a ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N,N?-bis(diphenylmethyl)-1,2-ethanediamine, dihydrochloride

Correlated keywords:

83027-13-8 1427369-96-7 AMN 082 82 mGlu GluR GluR7 R7b R7a R1b R4 R R8a R5a R3 R2 R6 NM DA NR 1a 2A 2B NR1 NR2 ?1AR NPC OH DA 6OHDA

Product Overview:
AMN082 is an orally bioavailable allosteric agonist of metabotropic glutamate receptor 7 (mGluR7).{47688} It inhibits cAMP accumulation induced by forskolin in CHO cells expressing human mGluR7b (EC50 = 64 nM). AMN082 (10 μM) is selective for mGluR7a and mGluR7b over mGluR1b, mGluR4, and mGluR8a with 140, 90, 15, 18, and 20% activation, respectively, as well as over mGluR2, mGluR3, mGluR5a, mGluR6, GluR3, and NMDA receptors containing NR1a, NR2A, or NR2B subunits. AMN082 also binds to the norepinephrine transporter (NET) and α1-adrenergic receptor (α1-AR).{47689} It increases the proliferation of neural progenitor cells (NPCs) and induces their differentiation into neurons when used at a concentration of 1 μM.{47690} AMN082 (2.5 mg/kg) inhibits apomorphine-induced circling in a rat model of Parkinson's disease induced by 6-hydroxy dopamine (6-OHDA; Item No. 25330).{47691}

Size	5 mg
Shipping	dry ice
CAS Number	97075-46-2
Molecular Formula	C₂₈H₂₈N₂ • 2HCl
SMILES	C(C1=CC=CC=C1)(C2=CC=CC=C2)NCCNC(C3=CC=CC=C3)C4=CC=CC=C4.Cl.Cl
Molecular Weight	465,5
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2921.29
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.