Pulchinenoside A

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Pulchinenoside A

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Cat No: 28545

Biochemicals - Ion Channel Modulation

Pulchinenoside A is a triterpenoid saponin that has been found in Pulsatilla chinensis and has diverse biological activities.{48595,48596} It inhibits NMDA-evoked currents in hippocampal neurons (IC50s = 18.48 and 20.19 μM at -50 and +50 mV, respectiv...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(3?,4?)-3-[[2-O-(6-deoxy-?-L-mannopyranosyl)-?-L-arabinopyranosyl]oxy]-23-hydroxy-lup-20(29)-en-28-oic acid

Correlated keywords:

5HT hydroxy indolacetic 5HIAA A 3

Product Overview:
Pulchinenoside A is a triterpenoid saponin that has been found in Pulsatilla chinensis and has diverse biological activities.{48595,48596} It inhibits NMDA-evoked currents in hippocampal neurons (IC50s = 18.48 and 20.19 μM at -50 and +50 mV, respectively) and inhibits NMDA-induced neuronal cell death when used at a concentration of 30 μM.{48596} Pulchinenoside A (30 and 100 mg/kg) increases the levels of serotonin (5-HT; Item No. 14332), 5-hydroxyindolacetic acid (5-HIAA; Item No. 22889), and norepinephrine (Item No. 16673) in the hippocampus and 5-HIAA and norepinephrine in the prefrontal cortex in mice. It reduces the time spent immobile in the forced swim test in mice when administered at doses of 30 and 100 mg/kg and increases the time spent in the target quadrant of the Morris water maze in mice at 100 mg/kg. Pulchinenoside A (12.6 and 25.2 mg/kg) reduces infarct volume in a middle cerebral artery occlusion (MCAO) rat model of ischemia. It also induces relaxation of precontracted isolated rat thoracic aorta and renal, mesenteric, and left coronary arteries in a concentration-dependent manner.{48595}

Size	5 mg
Shipping	dry ice
CAS Number	129724-84-1
Molecular Formula	C₄₁H₆₆O₁₂
SMILES	CC([C@@H]1CC[C@]2(C(O)=O)CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])[C@](C)(CO)[C@@H](O[C@H]6[C@H](O[C@H]7[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O7)[C@@H](O)[C@@H](O)CO6)CC[C@]5(C)[C@@]4([H])CC[C@]3([H])[C@]21[H])=C
Molecular Weight	751
Formulation	A solid
Purity	≥90%
Custom Code	2938.90
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.