Corticosterone-d8

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Corticosterone-d₈

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Cat No: 28524

Biochemicals - Isotopically Labeled Standards

Corticosterone-d8 is intended for use as an internal standard for the quantification of corticosterone (Item No. 16063) by GC- or LC-MS. Corticosterone is a steroid hormone produced in the cortex of the adrenal glands that binds to both glucocorticoid...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(11?)-11,21-dihydroxy-pregn-4-ene-3,20-dione-2,2,4,6,6,17,21,21-d8

Correlated keywords:

NSC 9705 NSC9705 deuterated deuterium d-8 11?,21DHPd8 17deoxy 11?,21dihydroxy DHPd8 11?,21DHP GCMS LCMS

Product Overview:
Corticosterone-d8 is intended for use as an internal standard for the quantification of corticosterone (Item No. 16063) by GC- or LC-MS. Corticosterone is a steroid hormone produced in the cortex of the adrenal glands that binds to both glucocorticoid and mineralocorticoid receptors.{26042} It is produced in response to adrenocorticotropic hormone (ACTH) and is the precursor to aldosterone synthesis.{19056} Since the production of glucocorticoids is increased by stress, it is often used as a biomarker of stress.{11468} Plasma corticosterone levels have a circadian variation and corticosterone may be important in the regulation of the sleep-wake cycle.{11469,11480}

Size	5 mg
Shipping	dry ice
CAS Number	1271728-07-4
Molecular Formula	C₂₁H₂₂D₈O₄
SMILES	O=C1C([2H])([2H])C[C@@]2(C)C(C([2H])([2H])C[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4([2H])C(C([2H])([2H])O)=O)=C1[2H]
Molecular Weight	354,5
Formulation	A solid
Purity	≥99% deuterated forms (d1-d8)
Custom Code	3822.19
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.