Felbamate-d4

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Felbamate-d₄

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Cat No: 28489

Biochemicals - Ion Channel Modulation

Felbamate-d4 is intended for use as an internal standard for the quantification of felbamate (Item No. 18000) by GC- or LC-MS. Felbamate is an inhibitor of NMDA receptors and a modulator of GABAA receptors that also has broad-spectrum inhibitory activ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-phenyl-1,3-propane-1,1,3,3-d4-diol dicarbamate

Correlated keywords:

deuterated deuterium GABA ?1 ?2 ?2S ?3 ?2 Xenopus ?2L ?4 ?6 ADD-03055 ADD03055

Product Overview:
Felbamate-d4 is intended for use as an internal standard for the quantification of felbamate (Item No. 18000) by GC- or LC-MS. Felbamate is an inhibitor of NMDA receptors and a modulator of GABAA receptors that also has broad-spectrum inhibitory activity against excitatory amino acid receptors.{45398,45399,45400} It binds to NMDA channels with dissociation constants of approximately 200, 110, and 55 µM in the resting, activated, and desensitized states, respectively, and inhibits NMDA currents in a use-dependent manner.{45398} Felbamate is a positive modulator of α1β2γ2S, α1β3γ2S, α2β2γ2S, and α2β3γ2S subunit-containing GABAA receptors expressed in X. laevis oocytes, with negative modulation of GABAA receptors containing the subunits α1β1, α1β3γ2L, α4β1γ2S, α4β3γ2S, and α6β1γ2S.{45399} It inhibits seizures induced by maximal electroshock, pentylenetetrazole (Item No. 18682), and picrotoxin (Item No. 20771) in mice (ED50s = 16.3, 5.51, and 5.23 mg/kg, respectively). Formulations containing felbamate have been used in the treatment of severe refractory seizures.

Size	500 µg
Shipping	dry ice
CAS Number	106817-52-1
Molecular Formula	C₁₁H₁₀D₄N₂O₄
SMILES	NC(OC([2H])([2H])C(C([2H])([2H])OC(N)=O)C1=CC=CC=C1)=O
Molecular Weight	242,3
Formulation	A solid
Purity	≥99% deuterated forms (d1-d4)
Custom Code	3822.19
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.