Cerevisterol

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Cerevisterol

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Cat No: 28466

Biochemicals - Natural Products

Cerevisterol is an ergosterol fungal metabolite originally isolated from S. cerevisiae that has diverse biological activities, including antimicrobial, anti-inflammatory, and anticancer properties.{45430} It is active against the bacteria S. typhi, S....

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(3?,5?,6?,22E)-ergosta-7,22-diene-3,5,6-triol

Correlated keywords:

2244768-40-7 Cerevisterin Trihydroxyergosta Saccharomyces salmonella Staphylococcus Enterococcus Aspergillus Escherichia Pseudomonas Streptococcus Klebsiella Bacillus Candida TNF? IL6 IL10 E-2 PGE-2 RAW264.7 MCF7 MDAMB-231 MDAMB231 MB231 Caco2 PC-3 PANC1 A-549 Staph Strep

Product Overview:
Cerevisterol is an ergosterol fungal metabolite originally isolated from S. cerevisiae that has diverse biological activities, including antimicrobial, anti-inflammatory, and anticancer properties.{45430} It is active against the bacteria S. typhi, S. aureus, and E. faecalis (MICs = 25, 25, and 50 µg/ml, respectively) and the fungus A. niger (MIC = 25 µg/ml), but has no effect on the bacteria E. coli, P. aeruginosa, S. pyogenes, K. pneumoniae, and B. subtilis, or the fungi C. albicans, A. flavus, and A. tamarii when used at concentrations up to 400 µg/ml.{45431} Cerevisterol (2-20 µM) inhibits LPS-induced increases in the levels of nitric oxide (NO), TNF-α, IL-6, IL-10, and prostaglandin E2 (PGE2; Item No. 14010) in RAW 264.7 cells.{45432} It inhibits proliferation of MCF-7, MDA-MB-231, and Caco-2 cancer cells (EC50s = 64.5, 52.4, and 37.6 µM, respectively), but not PC3, PANC-1, or A549 cells (IC50 = >100 µM for all).{45433},{45434}

Size	1 mg
Shipping	dry ice
CAS Number	516-37-0
Molecular Formula	C₂₈H₄₆O₃
SMILES	C[C@H](/C=C/[C@H](C)C(C)C)[C@@]1([H])CC[C@@]2([H])C3=C[C@@H](O)[C@@]4(O)C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
Molecular Weight	430,7
Formulation	A solid
Purity	≥70%
Custom Code	2937.29
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.