Coptisine (chloride)

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Cat No: 28424

Biochemicals - Natural Products

Coptisine is an isoquinoline alkaloid that has been found in Coptis chinensis and has diverse biological activities, including antioxidant, enzyme inhibitory, antiproliferative, and anti‑hypercholesterolemic properties.{47685,52041,47686,50112,50111} ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

6,7-dihydro-bis[1,3]benzodioxolo[5,6-a:4?,5?-g]quinolizinium, monochloride

Correlated keywords:

3486-66-6 anti-oxidant proliferative hyper-cholesterolemic antihypercholesterolemic DCFHDA DC FH A Ch E B BACE 1 OCT 2 3 MD CK 549 H 460 2170

Product Overview:
Coptisine is an isoquinoline alkaloid that has been found in Coptis chinensis and has diverse biological activities, including antioxidant, enzyme inhibitory, antiproliferative, and anti‑hypercholesterolemic properties.{47685,52041,47686,50112,50111} It inhibits the production of reactive oxygen species (ROS) in isolated kidney mitochondria in a 2,7-dichlorodihydrofluorescein diacetate (DCFH-DA; Item No. 85155) assay (IC50 = 48.93 μM).{47685} Coptisine inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) but not β-secretase 1 (BACE1) in cell-free enzyme assays (IC50s = 0.8, 5.81, and >100 μM, respectively). It also inhibits indoleamine 2,3-dioxygenase (IDO) in vitro (IC50 = 6.3 μM), as well as organic cation transporter 1 (OCT1), OCT2, and OCT3 in MDCK cells (IC50s = 0.931, 2.27, and 2.27 μM, respectively, for the human transporters).{52041,47686} It inhibits proliferation of A549, H460, and H2170 human lung cancer cells with IC50 values of 18.09, 29.5, and 21.6 μM, respectively.{50112} Coptisine (70.05 mg/kg) decreases total serum cholesterol, triglyceride, and LDL-cholesterol levels and increases serum HDL-cholesterol levels in Syrian golden hamsters fed a high-fat and high-cholesterol diet.{50111}

Size	10 mg
Shipping	dry ice
CAS Number	6020-18-4
Molecular Formula	C₁₉H₁₄NO₄ • Cl
SMILES	C1(OCO2)=C2C=C(CC[N+]3=CC4=C(OCO5)C5=CC=C4C=C36)C6=C1.[Cl-]
Molecular Weight	355,8
Formulation	A solid
Purity	≥98%
Custom Code	2933.39
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.