Coptisine (chloride)

Coptisine (chloride)

CAT N°: 28424
Price:

From €182.00 €154.70

Coptisine is an isoquinoline alkaloid that has been found in Coptis chinensis and has diverse biological activities, including antioxidant, enzyme inhibitory, antiproliferative, and anti?hypercholesterolemic properties.{47685,52041,47686,50112,50111} It inhibits the production of reactive oxygen species (ROS) in isolated kidney mitochondria in a 2,7-dichlorodihydrofluorescein diacetate (DCFH-DA; Item No. 85155) assay (IC50 = 48.93 ?M).{47685} Coptisine inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) but not ?-secretase 1 (BACE1) in cell-free enzyme assays (IC50s = 0.8, 5.81, and >100 ?M, respectively). It also inhibits indoleamine 2,3-dioxygenase (IDO) in vitro (IC50 = 6.3 ?M), as well as organic cation transporter 1 (OCT1), OCT2, and OCT3 in MDCK cells (IC50s = 0.931, 2.27, and 2.27 ?M, respectively, for the human transporters).{52041,47686} It inhibits proliferation of A549, H460, and H2170 human lung cancer cells with IC50 values of 18.09, 29.5, and 21.6 ?M, respectively.{50112} Coptisine (70.05 mg/kg) decreases total serum cholesterol, triglyceride, and LDL-cholesterol levels and increases serum HDL-cholesterol levels in Syrian golden hamsters fed a high-fat and high-cholesterol diet.{50111}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 6,7-dihydro-bis[1,3]benzodioxolo[5,6-a:4?,5?-g]quinolizinium, monochloride
  • Correlated keywords
    • 3486-66-6 anti-oxidant proliferative hyper-cholesterolemic antihypercholesterolemic DCFHDA DC FH A Ch E B BACE 1 OCT 2 3 MD CK 549 H 460 2170
  • Product Overview:
    Coptisine is an isoquinoline alkaloid that has been found in Coptis chinensis and has diverse biological activities, including antioxidant, enzyme inhibitory, antiproliferative, and anti?hypercholesterolemic properties.{47685,52041,47686,50112,50111} It inhibits the production of reactive oxygen species (ROS) in isolated kidney mitochondria in a 2,7-dichlorodihydrofluorescein diacetate (DCFH-DA; Item No. 85155) assay (IC50 = 48.93 ?M).{47685} Coptisine inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) but not ?-secretase 1 (BACE1) in cell-free enzyme assays (IC50s = 0.8, 5.81, and >100 ?M, respectively). It also inhibits indoleamine 2,3-dioxygenase (IDO) in vitro (IC50 = 6.3 ?M), as well as organic cation transporter 1 (OCT1), OCT2, and OCT3 in MDCK cells (IC50s = 0.931, 2.27, and 2.27 ?M, respectively, for the human transporters).{52041,47686} It inhibits proliferation of A549, H460, and H2170 human lung cancer cells with IC50 values of 18.09, 29.5, and 21.6 ?M, respectively.{50112} Coptisine (70.05 mg/kg) decreases total serum cholesterol, triglyceride, and LDL-cholesterol levels and increases serum HDL-cholesterol levels in Syrian golden hamsters fed a high-fat and high-cholesterol diet.{50111}

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