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(±)-Synephrine (hydro
chloride)
(±)-Synephrine (hydro
-
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Cat No: 28398
Biochemicals
- Receptor Pharmacology
(±)-Synephrine is an alkaloid with vasoconstrictor and metabolic activities.{53000,53001,53002} It binds to α1A-, α2A-, and α2C-adrenergic receptors (ARs; Kis = 78, 36.7, and 24.4 µM, respectively).{53003} (±)-Synephrine is an agonist of α1A-ARs in HE...
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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
- 4-hydroxy-?-[(methylamino)methyl]-benzenemethanol, monohydrochloride
Correlated keywords:
- 582-84-3 860222-98-6 Sympatol Oxedrine p-synephrine ?-1A 2A 2C ?1AARs HEK-293 ?2AARs ?2CARs Glut-4 ?2AR
Product Overview:
(±)-Synephrine is an alkaloid with vasoconstrictor and metabolic activities.{53000,53001,53002} It binds to α1A-, α2A-, and α2C-adrenergic receptors (ARs; Kis = 78, 36.7, and 24.4 µM, respectively).{53003} (±)-Synephrine is an agonist of α1A-ARs in HEK293 cells (EC50 = 4 µM in a reporter assay) but not in CHO cells expressing α2A- or α2C-AR. It also acts as an antagonist of α1A-, α2A-, and α2C-ARs, inhibiting L-phenylephrine-induced activation of α1A-AR in HEK293 cells and activation of α2A- and α2C-ARs induced by the α2-AR agonist medetomidine in CHO cells (IC50s = 12.8, 26, and 27.3 µM, respectively, in reporter assays). (±)-Synephrine induces contractions in isolated rabbit aortic rings (EC50 = 6.2 µg/ml) and increases ligation-induced mean arterial pressure in rats when administered at a dose of 2 mg/kg per day.{53000,53004} It induces lipolysis in isolated rat and human adipocytes when used at concentrations of 100 and 1,000 µg/ml.{53001} (±)-Synephrine (50 µM) increases phosphorylation of Akt and AMP-activated protein kinase (AMPK) and translocation of Glut4 to the plasma membrane, as well as increases insulin-induced glucose consumption in L6 muscle cells when used at concentrations ranging from 25 to 200 µM.{53002}
(±)-Synephrine is an alkaloid with vasoconstrictor and metabolic activities.{53000,53001,53002} It binds to α1A-, α2A-, and α2C-adrenergic receptors (ARs; Kis = 78, 36.7, and 24.4 µM, respectively).{53003} (±)-Synephrine is an agonist of α1A-ARs in HEK293 cells (EC50 = 4 µM in a reporter assay) but not in CHO cells expressing α2A- or α2C-AR. It also acts as an antagonist of α1A-, α2A-, and α2C-ARs, inhibiting L-phenylephrine-induced activation of α1A-AR in HEK293 cells and activation of α2A- and α2C-ARs induced by the α2-AR agonist medetomidine in CHO cells (IC50s = 12.8, 26, and 27.3 µM, respectively, in reporter assays). (±)-Synephrine induces contractions in isolated rabbit aortic rings (EC50 = 6.2 µg/ml) and increases ligation-induced mean arterial pressure in rats when administered at a dose of 2 mg/kg per day.{53000,53004} It induces lipolysis in isolated rat and human adipocytes when used at concentrations of 100 and 1,000 µg/ml.{53001} (±)-Synephrine (50 µM) increases phosphorylation of Akt and AMP-activated protein kinase (AMPK) and translocation of Glut4 to the plasma membrane, as well as increases insulin-induced glucose consumption in L6 muscle cells when used at concentrations ranging from 25 to 200 µM.{53002}
| Size | 5 g |
| Shipping | dry ice |
| CAS Number | 5985-28-4 |
| Molecular Formula | C9H13NO2 • HCl |
| SMILES | OC1=CC=C(C(O)CNC)C=C1 |
| Molecular Weight | 203,7 |
| Formulation | A crystalline solid |
| Purity | ≥95% |
| Custom Code | 2922.50 |
| UNSPSC code | 12352100 |
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