Anthralin

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Anthralin

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Cat No: 28371

Biochemicals - More Biochemicals

Anthralin is an anthrone inhibitor of keratinocyte proliferation and a modulator of differentiation.{45558} It increases apoptosis and inhibits proliferation of normal human keratinocytes (NHKs) when used at a concentration of 2.5 μM. It also decrease...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1,8-dihydroxy-9(10H)-anthracenone

Correlated keywords:

Anthra-Derm AnthraDerm anthrone Batidrol Batridol Chrysodermol Cignolin Cigthranol Derobin DrithoCreme Drithoscalp Lasan Psodadrate Psoriacid-Stift PsoriacidStift Psoriacide Dihydroxyanthrone Dihydroxyanthranol ?defensin defensin2 ?defensin2 S-100 A-9 IL6 IL8 IL17A IL22 B-4 LTB 23187

Product Overview:
Anthralin is an anthrone inhibitor of keratinocyte proliferation and a modulator of differentiation.{45558} It increases apoptosis and inhibits proliferation of normal human keratinocytes (NHKs) when used at a concentration of 2.5 μM. It also decreases the mitochondrial membrane potential, increases cytochrome c release, and induces perinuclear mitochondrial clustering in NHKs when used at a concentration of 5 μM.{45559} Anthralin (0.25 μM) decreases the expression of β-defensin-2 (Item No. 24577) and S100 calcium-binding protein A9 (S100A9) and increases the expression of IL-6 and IL-8 in IL-17A- and IL-22-stimulated NHKs.{45558} It also inhibits leukotriene B4 (LTB4; Item No. 20110) production, stimulated by the calcium ionophore A23187 (Item No. 11016), from human neutrophils (IC50 = 7 μM).{342} Topical anthralin (0.1%) induces hair regrowth in a Dundee experimental bald rat (DEBR) model of alopecia areata.{45560}

Size	1 g
Shipping	dry ice
CAS Number	1143-38-0
Molecular Formula	C₁₄H₁₀O₃
SMILES	OC1=C2C(CC(C=CC=C3O)=C3C2=O)=CC=C1
Molecular Weight	226,2
Formulation	A crystalline solid
Purity	≥90%
Custom Code	2907.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.