Desoximetasone-d3

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Desoximetasone-d₃

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Cat No: 28159

Biochemicals - Isotopically Labeled Standards

Desoximetasone-d3 is intended for use as an internal standard for the quantification of desoximetasone (Item No. 23945) by GC- or LC-MS. Desoximetasone is a glucocorticoid.{39559} In vivo, desoximetasone (0.001-0.1 mg) reverses increases in epidermal ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

9-fluoro-11?,21-dihydroxy-16?-methyl-pregna-1,4-diene-3,20-dione-d3

Correlated keywords:

A-41-304 A41-304 HOE-304 HOE304 deuterated deuterium IL6 COX2 cJun deoxyDexamethasone antiinflammatory 382-67-2 GCMS LCMS SEN CAR NOS RNA A41304

Product Overview:
Desoximetasone-d3 is intended for use as an internal standard for the quantification of desoximetasone (Item No. 23945) by GC- or LC-MS. Desoximetasone is a glucocorticoid.{39559} In vivo, desoximetasone (0.001-0.1 mg) reverses increases in epidermal cell proliferation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in SENCAR mice when administered topically. It also reduces TPA-induced expression of IL-6, COX-2, iNOS, and c-Jun mRNA levels in the skin of SENCAR mice, indicating anti-inflammatory action. Formulations containing desoximetasone have been used in the treatment of psoriasis and atopic dermatitis.

Size	1 mg
Shipping	dry ice
Molecular Formula	C₂₂H₂₆D₃FO₄
SMILES	O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@]4([2H])C(C([2H])([2H])O)=O)=C1
Molecular Weight	379,5
Formulation	A solid
Purity	≥99% deuterated forms (d1-d3)
Custom Code	3822.19
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.