Ara-G

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Ara-G

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Cat No: 27984

Biochemicals - Small Molecule Inhibitors

Ara-G is an analog of the nucleoside guanosine and an active metabolite of nelarabine (Item No. 20248).{47551,47552} Ara-G accumulates in T lymphoblasts and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporated int...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-amino-9-?-D-arabinofuranosyl-1,9-dihydro-6H-purin-6-one

Correlated keywords:

16639-98-8 Arabinoguanosine Araguanosine NSC76352 anti-cancer AraG lympho-blasts araGTP subG1 subG G1 6C3 HED 9-?-D-Arabinofuranosylguanine

Product Overview:
Ara-G is an analog of the nucleoside guanosine and an active metabolite of nelarabine (Item No. 20248).{47551,47552} Ara-G accumulates in T lymphoblasts and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporated into the DNA.{32256,47551} Ara-G inhibits DNA replication by 92% after 30 minutes when used at a concentration of 50 µM in CEM cells, which are used as a model for human T lymphoblasts.{47551} It also halts the cell cycle at the sub-G1 phase and induces apoptosis in CEM cells.{32256} Syngeneic bone marrow containing 6C3HED tumor cells treated with ara-G (100 mM) ex vivo prior to transplantation increases survival of lethally irradiated mice and induces reconstitution of lymphoid, myeloid, and erythroid cell linages.{47553}

Size	50 mg
Shipping	dry ice
CAS Number	38819-10-2
Molecular Formula	C₁₀H₁₃N₅O₅
SMILES	O[C@H]1[C@H](O)[C@H](N2C=NC3=C2NC(N)=NC3=O)O[C@@H]1CO
Molecular Weight	283,2
Formulation	A solid
Purity	≥95%
Custom Code	2932.19
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.