Z-Phe-Tyr(tBu)-diazomethylketone

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Cat No: 27877

Z-Phe-Tyr(tBu)-diazomethylketone is an inhibitor of cathepsin L (Kinact = 200,000 M-1s-1).{42899,42900} It is selective for cathepsin L over cathepsin S and cathepsin B (Kinacts = 30 and 10.3 M-1s-1, respectively). Z-Phe-Tyr(tBu)-diazomethylketone...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-[(1S)-2-[[(1S)-3-diazo-1-[[4-(1,1-dimethylethoxy)phenyl]methyl]-2-oxopropyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-carbamic acid, phenylmethyl ester

Correlated keywords:

Trypanosoma 427-221-a Z-FY(t-Bu)-DMK ZFY-tBu

Product Overview:
Z-Phe-Tyr(tBu)-diazomethylketone is an inhibitor of cathepsin L (Kinact = 200,000 M-1s-1).{42899,42900} It is selective for cathepsin L over cathepsin S and cathepsin B (Kinacts = 30 and 10.3 M-1s-1, respectively). Z-Phe-Tyr(tBu)-diazomethylketone is active against bloodstream forms of T. brucei brucei clone 427-221a in vitro (EC50 = 126 μM).{41145}

Size	1 mg
Shipping	dry ice
CAS Number	114014-15-2
Molecular Formula	C₃₁H₃₄N₄O₅
SMILES	O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@H](C(C=[N+]=[N-])=O)CC2=CC=C(OC(C)(C)C)C=C2)=O)OCC3=CC=CC=C3
Molecular Weight	542,6
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2921.29
UNSPSC code	12352100

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