Xanthotoxol

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Xanthotoxol

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Cat No: 27801

Biochemicals - Natural Products

Xanthotoxol is a coumarin and a major component in C. monnieri that has diverse biological activities.{47083,45339,45340,45341,45342} It inhibits proliferation of HeLa and HepG2 cells in vitro (IC50s = 23.59 and 15.57 μM, respectively).{47083} Xanthot...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

9-hydroxy-7H-furo[3,2-g][1]benzopyran-7-one

Correlated keywords:

5-Benzofuranacrylic acid 6-7-dihydroxy ?-lactone 8-hydroxy-psoralen 2-Propenoic benzofuranyl benzo-furanyl Cnidium HepG Hep-G2 TNF? IL4 IL1? RBL2H3 2H-3 Meloidogyne hyper-mobility IL8 ICAM1 NSC401269

Product Overview:
Xanthotoxol is a coumarin and a major component in C. monnieri that has diverse biological activities.{47083,45339,45340,45341,45342} It inhibits proliferation of HeLa and HepG2 cells in vitro (IC50s = 23.59 and 15.57 μM, respectively).{47083} Xanthotoxol increases histamine release from mast cells and decreases secretion of TNF-α, IL-4, and IL-1β from RBL-2H3 cells induced by DNP-human serum albumin (DNP-HSA).{45339} It is nematocidal against M. incognita (IC50 = 68 mg/L).{45340} In vivo, xanthotoxol inhibits predatory mouse and rat killing behavior in dogs and cats when administered at doses ranging from 3 to 100 mg/kg and 5 to 20 mg/kg, respectively.{45341} It reduces amphetamine-induced hypermobility in mice and hamsters. Xanthotoxol (5 and 10 mg/kg) reduces brain edema, neutrophil infiltration, blood-brain barrier disruption, production of IL-1β, TNF-α, IL-8, and nitric oxide (NO), and levels of intercellular adhesion molecule-1 (ICAM-1) and E-selectin in a rat model of focal cerebral ischemia.{45342}

Size	5 mg
Shipping	dry ice
CAS Number	2009-24-7
Molecular Formula	C₁₁H₆O₄
SMILES	OC1=C(OC=C2)C2=CC(C=C3)=C1OC3=O
Molecular Weight	202,2
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2907.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.