Swertiamarin

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Swertiamarin

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Cat No: 27634

Biochemicals - Natural Products

Swertiamarin is an orally bioavailable secoiridoid glycoside that has been found in E. axillare and has diverse biological activities, including antioxidant, anti-inflammatory, antidiabetic, and hepatoprotective properties.{53028,53029,53030,53031,530...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(4aR,5R,6S)-5-ethenyl-6-(?-D-glucopyranosyloxy)-4,4a,5,6-tetrahydro-4a-hydroxy-1H,3H-pyrano[3,4-c]pyran-1-one

Correlated keywords:

28633-33-2 Swertiamarine Swertiamaroside Swertamarin Swertimarin Enicostema anti-oxidant diabetic antiinflammatory hepato-protective IL1? Hep-G2 TNF? IL6

Product Overview:
Swertiamarin is an orally bioavailable secoiridoid glycoside that has been found in E. axillare and has diverse biological activities, including antioxidant, anti-inflammatory, antidiabetic, and hepatoprotective properties.{53028,53029,53030,53031,53032} It scavenges ABTS (Item No. 27317) radicals and hydrogen peroxide (IC50s = 2.83 and 5.7 μM, respectively).{53028} Swertiamarin (50 μg/ml) inhibits nitric oxide (NO) production in IL-1β-stimulated fibroblast-like synoviocytes (FLSs) isolated from rat hindpaw.{53029} Swertiamarin (25 μg/ml) inhibits oleate-induced lipid droplet and triglyceride accumulation in HepG2 cells.{53031} It decreases liver lipid accumulation, ballooning degeneration, and TNF-α and IL-6 levels in a mouse model of fructose-induced nonalcoholic fatty liver disease (NAFLD) when administered at a dose of 50 mg/kg per day.{53032} Swertiamarin (50 mg/kg per day) also decreases fasting blood glucose and serum cholesterol levels in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104).{53030}

Size	10 mg
Shipping	dry ice
CAS Number	17388-39-5
Molecular Formula	C₁₆H₂₂O₁₀
SMILES	O=C1OCC[C@]2(O)C1=CO[C@@H](O[C@]3([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H]2C=C
Molecular Weight	374,3
Formulation	A solid
Purity	≥98%
Custom Code	2938.90
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.