Glp-Amyloid-? (3-40) Peptide (hu

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Glp-Amyloid-? (3-40) Peptide (human) (trifluoroacetate salt)

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Cat No: 27416

Biochemicals - Peptides

Glp-Amyloid-β (3-40) peptide is a fragment of amyloid-β (1-40) (Aβ40; Item No. 21617) that contains the cyclic amino acid pyroglutamate at the N-terminus. Glp-Amyloid-β (3-40) peptide is a major component of the endogenous amyloid-β content in post-mo...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5-oxo-L-prolyl-L-phenylalanyl-L-arginyl-L-histidyl-L-?-aspartyl-L-serylglycyl-L-tyrosyl-L-?-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-?-glutamyl-L-?-aspartyl-L-valylglycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-methionyl-L-valylglycylglycyl-L-valyl-L-valine, trifluoroacetate salt

Correlated keywords:

161818-04-8 220526-58-9 257941-94-9 amyloid? A? 40 42 APP 23 GlpFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV A?(N3pE40)

Product Overview:
Glp-Amyloid-β (3-40) peptide is a fragment of amyloid-β (1-40) (Aβ40; Item No. 21617) that contains the cyclic amino acid pyroglutamate at the N-terminus. Glp-Amyloid-β (3-40) peptide is a major component of the endogenous amyloid-β content in post-mortem brain tissue from patients with Alzheimer’s disease.{50304} It is formed through cleavage of the N-terminal aspartate and alanine on Aβ40 and Aβ42 followed by dehydration of glutamic acid by glutaminyl cyclase.{50305} Glp-Amyloid-β (3-40) peptide has been used as a reference peptide for the quantification of total pyroglutamate amyloid-β in APP23 mouse brain.{50304}

Size	100 µg
Shipping	dry ice
Molecular Formula	C₁₈₇H₂₈₃N₅₁O₅₃S • XCF₃COOH
SMILES	O=C(O)C(F)(F)F.O=C(N([H])[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@@H](CO)C(NCC(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C
Molecular Weight	4125,7
Formulation	A solid
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.