Hispidulin

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Hispidulin

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Cat No: 26383

Biochemicals - Kinase Inhibitors

Hispidulin is a flavonoid originally isolated from A. montana with diverse biological activities.{45323,45324,45325,45326,45327} It inhibits platelet aggregation induced by platelet-activating factor (PAF), arachidonic acid (Item Nos. 90010
90010.1 ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one

Correlated keywords:

6-Methylscutellarein Hispedulin Hispiludin Salvitin Scutellarein methyl ether methoxyflavone Acacia Caki2 SPHK-1 NSC122415 methoxy apigenin RAW264.7 lipopolysaccharide 4',5,7-Trihydroxy methoxy-flavone

Product Overview:
Hispidulin is a flavonoid originally isolated from A. montana with diverse biological activities.{45323,45324,45325,45326,45327} It inhibits platelet aggregation induced by platelet-activating factor (PAF), arachidonic acid (Item Nos. 90010
90010.1
10006607), and ADP (IC50s = 20, 4, and 13 μM, respectively).{45323} Hispidulin inhibits RANKL-induced osteoclastic differentiation of RAW 264.7 cells and bone marrow-derived macrophages (BMMs).{45324} In vivo, hispidulin (25 μg/kg) inhibits LPS-induced bone resorption in mice. It inhibits sphingosine kinase 1 (SPHK1) and induces ceramide accumulation and apoptosis in Caki-2 renal carcinoma cells in vitro and inhibits tumor growth in a Caki-2 mouse xenograft model.{45325} Pretreatment with hispidulin (40 mg/kg) reduces cognitive deficits in the Morris water maze induced by sevoflurane (Item No. 23996) in aged rats.{45326} It also decreases infarct size and brain edema in a rat model of focal cerebral ischemia and reperfusion injury.{45327}

Size	1 mg
Shipping	dry ice
CAS Number	1447-88-7
Molecular Formula	C₁₆H₁₂O₆
SMILES	OC1=C(OC)C(O)=C(C(C=C(C2=CC=C(O)C=C2)O3)=O)C3=C1
Molecular Weight	300,3
Formulation	A solid
Purity	≥95%
Custom Code	2907.29
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.