CC-122

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CC-122

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Cat No: 26257

Biochemicals - More Biochemicals

CC-122 is a pleiotropic pathway modifier with anticancer activity.{50163} It binds to cereblon, a substrate receptor protein of the Cullin 4 RING E3 ubiquitin ligase complex, in U266 multiple myeloma cell extracts and induces recruitment and degradati...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-(5-amino-2-methyl-4-oxo-3(4H)-quinazolinyl)-2,6-piperidinedione

Correlated keywords:

quinazolin piperidine oxoquinazolin piperidine dione CC122 anti-cancer E-3 U-266 TMD-8 OCILY10 OCI-LY-10 OCILY Karpas422 IL2 OCI-LY10ABCDLBCL ABCDLBCL LY10ABC OCILY10ABC WSU-DLCL2GCBDLBCL WSUDLCL2 GCBDLBCL WSUDLCL2GCB 422DLBCL IL2 interleukin

Product Overview:
CC-122 is a pleiotropic pathway modifier with anticancer activity.{50163} It binds to cereblon, a substrate receptor protein of the Cullin 4 RING E3 ubiquitin ligase complex, in U266 multiple myeloma cell extracts and induces recruitment and degradation of the cereblon substrates Aiolos and Ikaros in TMD8, OCI-LY10, and Karpas 422 diffuse large B cell lymphoma (DLBCL) cells when used at concentrations of 0.1, 1, and 10 μM. CC-122 (0.1-10,000 nM) decreases proliferation and induces apoptosis in activated B cell (ABC) and germinal center B cell (GCB) DLBCL cell lines. It also stimulates IL-2 production in mouse primary T cells. CC-122 (30 mg/kg) decreases tumor levels of Aiolos and Ikaros and reduces tumor growth in OCI-LY10 ABC DLBCL and WSU-DLCL2 GCB DLBCL mouse xenograft models.

Size	1 mg
Shipping	dry ice
CAS Number	1015474-32-4
Molecular Formula	C₁₄H₁₄N₄O₃
SMILES	O=C1C2=C(N)C=CC=C2N=C(C)N1C3CCC(NC3=O)=O
Molecular Weight	286,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2921.30
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.