Sordarin (sodium salt)

Sordarin (sodium salt)

CAT N°: 26255
Price:

From 182.00 154.70

Sordarin is an inhibitor of fungal protein synthesis originally isolated from S. araneosa.{48051} It binds to elongation factor 2 (EF-2) in the presence of ribosomes and inhibits the uncoupled GTPase activity of equimolar mixtures of EF-2 and ribosomes from C. albicans (IC50 = 0.1 ?M). Sordarin inhibits protein synthesis in cell-free lysates of C. albicans, C. glabrata, and C. neoformans (IC50s = 0.01, 0.2, and 0.06 ?g/ml, respectively) but not in rabbit reticulocytes (IC50 = >100 ?g/ml).{48052} It inhibits the growth of C. albicans (MIC = 8 ?g/ml) but not C. glabrata or C. neoformans (MICs = >125 ?g/ml).

We also advise you