Acipimox

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Acipimox

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Cat No: 26090

Biochemicals - More Biochemicals

Acipimox is an antilipolytic agent.{36963} It inhibits lipolysis induced by noradrenaline and theophylline in rat epididymal adipocytes when used at a concentration of 1 μM. Acipimox (3 and 12 mg/kg, p.o.) decreases plasma free fatty acid levels in ra...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5-methyl-2-pyrazinecarboxylic acid, 4-oxide

Correlated keywords:

olbemox olbetam K 9321 K9321 anti-lipolytic MMP2

Product Overview:
Acipimox is an antilipolytic agent.{36963} It inhibits lipolysis induced by noradrenaline and theophylline in rat epididymal adipocytes when used at a concentration of 1 μM. Acipimox (3 and 12 mg/kg, p.o.) decreases plasma free fatty acid levels in rats. It reduces plasma fatty acid concentration, the number of atherosclerotic plaques, and matrixmetalloproteinase-2 (MMP-2) activity in ApoE-/- mice fed a palmitate-rich diet.{36965} Acipimox also reduces fasting blood glucose and plasma insulin levels as well as plasma free fatty acid and triglyceride levels in a rat model of diabetes induced by streptozotocin (Item No. 13104).{36964} Formulations containing acipimox have been used in the treatment of hyperlipidemia in patients with non-insulin-dependent diabetes.

Size	500 mg
Shipping	dry ice
CAS Number	51037-30-0
Molecular Formula	C₆H₆N₂O₃
SMILES	CC1=CN=C(C(O)=O)C=[N+]1[O-]
Molecular Weight	154,1
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2933.59
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.