Raltitrexed

Raltitrexed

CAT N°: 26079
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From 92.00 78.20

Raltitrexed is an inhibitor of thymidylate synthase (Ki = 62 nM).{36978} It inhibits the growth of L1210 mouse lymphocytic leukemia cells in vitro (IC50 = 8 nM) as well as reduces thymidylate synthase activity and completely eliminates tumors in a mouse L1210:ICR ascitic tumor model when administered at a dose of 4 mg/kg, effects that can be reversed by administration of thymidine. It also reduces tumor growth and the number of metastases in an HCT116-luc mouse xenograft model.{36979} Formulations containing raltitrexed have been used in the treatment of advanced colorectal cancers.

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