Gastrin I (human)

Gastrin I (human)

CAT N°: 24457
Price:

437.00 371.45

Gastrin I is an endogenous, gastrointestinal peptide hormone that binds to cholecystokinin (CCK) receptors on human gastric leiomyosarcoma cells (IC50 = 0.9 nM) and in guinea pig gallbladder and pancreatic tissue (IC50s = 1.7 and 2.5 ?M, respectively).{36434,36435} It increases levels of cytosolic calcium in isolated rabbit stomach parietal cells (EC50 = 11 nM) and stimulates pepsinogen secretion by isolated human peptic cells (ED50 = 30 nM).{36436,36437} Gastrin I increases histidine decarboxylase (HDC) activity ex vivo in fundic stomach mucosa homogenate and increases gastric acid secretion in vivo in rats when administered at a dose of 1 nmol/kg/h.{36438}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 5-oxo-L-prolylglycyl-L-prolyl-L-tryptophyl-L-leucyl-L-?-glutamyl-L-?-glutamyl-L-?-glutamyl-L-?-glutamyl-L-?-glutamyl-L-alanyl-L-tyrosylglycyl-L-tryptophyl-L-methionyl-L-?-aspartyl-L-phenylalaninamide
  • Correlated keywords
    • 81615-84-1 84284-13-9 94885-13-9 95574-92-8 95676-75-8 464942-79-8 643753-59-7
  • Product Overview:
    Gastrin I is an endogenous, gastrointestinal peptide hormone that binds to cholecystokinin (CCK) receptors on human gastric leiomyosarcoma cells (IC50 = 0.9 nM) and in guinea pig gallbladder and pancreatic tissue (IC50s = 1.7 and 2.5 ?M, respectively).{36434,36435} It increases levels of cytosolic calcium in isolated rabbit stomach parietal cells (EC50 = 11 nM) and stimulates pepsinogen secretion by isolated human peptic cells (ED50 = 30 nM).{36436,36437} Gastrin I increases histidine decarboxylase (HDC) activity ex vivo in fundic stomach mucosa homogenate and increases gastric acid secretion in vivo in rats when administered at a dose of 1 nmol/kg/h.{36438}

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