Dapsone

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Dapsone

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Cat No: 23743

Dapsone is an anti-inflammatory, antimalarial, and antibacterial compound.{28213} In vivo, dapsone (34 μg/animal per day) reduces epidermal hyperproliferation and epithelial thickness in the esophagus in a mouse model of proliferative dermatitis.{3850...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4,4'-sulfonylbis-benzenamine

Correlated keywords:

1246638-15-2 Sulfonylbisaniline Sulfonylbisbenzamine Sulfonyldianiline Sulfonyldiphenylamine Sulphonyldianiline 4-Aminophenyl Aczone Aradur-9664-1 976-1 Araldite HT 976 Atrisone Avlosulfon Avlosulfone Croysulfone DADFS DADPS DSS Dapson Diaphenylsulfon Diaphenylsulfone; Diphenasone Diphone Disulone Dumitone Eporal F-1358 HB-MC-GE 40 45 HEW 62 HT 9664 HT976 HY 976 Hardener Lapox K 10 Metabolite C NSC6091 Novophone Seikacure S Servidapson Sulfona-Mae Sulphadione Sumicure Udolac p,p'-antiinflammatory anti-malarial bacterial Mycobacterium Plasmodium F1358 HT9664 HY976 1358F DDS Diaminobiphenyl MPO

Product Overview:
Dapsone is an anti-inflammatory, antimalarial, and antibacterial compound.{28213} In vivo, dapsone (34 μg/animal per day) reduces epidermal hyperproliferation and epithelial thickness in the esophagus in a mouse model of proliferative dermatitis.{38501} It reduces lipid peroxidation, myeloperoxidase activity, and cellular apoptosis in the striatum of rats following ischemia and reperfusion injury.{38502} Dapsone reduces growth of M. leprae in the footpad of mice (MIC = 0.01-0.03 μg/ml in sera) and induces clearance of P. knowlesi infections in macaques.{38503,38504} It also reduces the number of P. gallinaceum sporozoites in a mosquito population allowed to feed on dapsone-treated chicks.{38504} Formulations containing dapsone have been used in the treatment of malaria, acne, dermatitis, and leprosy.

Size	50 g
Shipping	dry ice
CAS Number	80-08-0
Molecular Formula	C₁₂H₁₂N₂O₂S
SMILES	NC1=CC=C(S(C2=CC=C(N)C=C2)(=O)=O)C=C1
Molecular Weight	248,3
Formulation	A solid
Purity	≥98%
Custom Code	2930.90
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.