PPTN (hydro<wbr/>chloride)

PPTN (hydrochloride)

CAT N°: 36854
Price:

From 60.00 51.00

PPTN is an antagonist of the purinergic P2Y14 receptor.{66094} It inhibits forskolin-induced cyclic AMP accumulation in C6 cells expressing human P2Y14 (EC50 = ~10 nM) but not CHO cells expressing P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 at 1 µM. PPTN (5 µM) inhibits UDP-glucose-induced IL-1? and chemokine (C-C motif) ligand 2 (CCL2) secretion, as well as ERK, JNK, and p38 MAPK phosphorylation in isolated rat satellite glial cells (SGCs).{66095} Trigeminal administration of PPTN (5 and 10 µM) reduces mechanical hyperalgesia induced by complete Freund’s adjuvant (CFA) in rats.{66096}

We also advise you