24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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From €94.00 €79.90
Polygalasaponin F is a triterpenoid saponin originally isolated from Polygala japonica and has diverse biological activities.{52413,52414,52415} It inhibits LPS-induced increases in TNF-? and nitric oxide (NO) production, inducible nitric oxide synthase (iNOS) levels, and nuclear translocation of NF-?B p65 in BV-2 microglia when used at concentrations of 0.1, 1, and 10 ?M.{52413} Polygalasaponin F (0.1, 1, and 10 ?M) inhibits rotenone-induced increases in intracellular reactive oxygen species (ROS) levels, decreases in mitochondrial membrane potential, and induction of apoptosis in PC12 cells.{52414} Intracerebroventricular administration of polygalasaponin F (1 and 10 ?M) induces long-term potentiation in the hippocampal dentate gyrus in anesthetized rats, an effect that can be prevented by the NMDA receptor inhibitor MK-801 or the calcium/calmodulin-dependent protein kinase (CaMKII) inhibitor KN-93 (Item Nos. 13319 | 13864 | 21472).{52415}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 25 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 882664-74-6 |
| Molecular formula | C53H86O23 |
| Smiles | OC[C@H]([C@@H](O)[C@H](O)[C@H]1O)O[C@H]1O[C@H]2[C@@H](O)C[C@]3(C)[C@@]4([H])CC=C5[C@]6([H])CC(C)(C)CC[C@]6(C(O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O[C@@H]8O[C@@H](C)[C@H](O[C@@H]9OC[C@@H](O)[C@H](O)[C@H]9O)[C@@H](O)[C@H]8O)=O)CC[C@@]5(C)[C@]4(C)CC[C@@]3([H])[C@]2(C)CO |
| Molecular weight | 1091,2 |
| Custom code | 2938.90 |
| Formulation | A solid |
| Purity | ≥95% |
| UNSPSC code | 12352100 |
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