Pitolisant

Pitolisant

CAT N°: 19307
Price:

From 55.00 46.75

Pitolisant is a nonimidazole histamine H3 receptor antagonist (Ki = 0.16 nM) and inverse agonist (EC50 = 1.5 nM).{47015} It increases the levels of tele-methylhistamine in mouse brain, indicating histaminergic neuron activity, with an ED50 value of 1.6 mg/kg. Pitolisant also increases dopamine and acetylcholine levels in the rat prefrontal cortex when administered at a dose of 10 mg/kg. It decreases the time spent in slow wave sleep and increases the time spent awake in cats. Pitolisant (2.5 and 5 mg/kg), when administered post-training, facilitates contextual fear memory consolidation and reverses dizocilpine-induced amnesia in mice.{47016} When administered following reactivation, it reverses dizocilpine-induced reconsolidation deficits.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-piperidine, monohydrochloride
  • Correlated keywords
    • 362665-56-3 BF2649 2.649 BF2.649 H-3 Ciproxidine non-imidazole telemethylhistamine
  • Product Overview:
    Pitolisant is a nonimidazole histamine H3 receptor antagonist (Ki = 0.16 nM) and inverse agonist (EC50 = 1.5 nM).{47015} It increases the levels of tele-methylhistamine in mouse brain, indicating histaminergic neuron activity, with an ED50 value of 1.6 mg/kg. Pitolisant also increases dopamine and acetylcholine levels in the rat prefrontal cortex when administered at a dose of 10 mg/kg. It decreases the time spent in slow wave sleep and increases the time spent awake in cats. Pitolisant (2.5 and 5 mg/kg), when administered post-training, facilitates contextual fear memory consolidation and reverses dizocilpine-induced amnesia in mice.{47016} When administered following reactivation, it reverses dizocilpine-induced reconsolidation deficits.

We also advise you