(+)-Pinoresinol

(+)-Pinoresinol

CAT N°: 27700
Price:

From €85.00 €72.25

(+)-Pinoresinol is a lignan that has been found in Forsythia and virgin olive oils and has diverse biological activities, including antioxidant, anticancer, and anti-inflammatory properties.{45351,45352,45353,45354} It is an inhibitor of ?-glucosidase and maltase (IC50s = 492 and 34.3 µM in Baker’s yeast and rat small intestine, respectively).{45353} (+)-Pinoresinol scavenges ABTS (Item No. 27317), but not 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805), radicals in cell-free assays (IC50s = 13.43 and >200 µg/ml, respectively).{45352} It is cytotoxic to A549, HepG2, and MCF-7, but not U251 and Bcap-37, cells with IC50 values of 29.35, 62.35, 75.32, >80, and >80 µM, respectively. (+)-Pinoresinol prevents cell death induced by glutamate in HT22 cells (EC50 = 6.96 µM) and inhibits LPS-induced nitric oxide production in RAW 264.7 cells (IC50 = 7.89 µM).{45354}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 4,4′-[(1S,3aR,4S,6aR)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis[2-methoxy-phenol
  • Correlated keywords
    • 18779-54-9 22658-90-8 d NSC35444 stereoisomer methoxyphenol anti-cancer oxidant A-549 HepG-2 MCF7 U-251 Bcap37 HT-22 Hep-G2 antiinflammatory lipopolysaccharide
  • Product Overview:
    (+)-Pinoresinol is a lignan that has been found in Forsythia and virgin olive oils and has diverse biological activities, including antioxidant, anticancer, and anti-inflammatory properties.{45351,45352,45353,45354} It is an inhibitor of ?-glucosidase and maltase (IC50s = 492 and 34.3 µM in Baker’s yeast and rat small intestine, respectively).{45353} (+)-Pinoresinol scavenges ABTS (Item No. 27317), but not 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805), radicals in cell-free assays (IC50s = 13.43 and >200 µg/ml, respectively).{45352} It is cytotoxic to A549, HepG2, and MCF-7, but not U251 and Bcap-37, cells with IC50 values of 29.35, 62.35, 75.32, >80, and >80 µM, respectively. (+)-Pinoresinol prevents cell death induced by glutamate in HT22 cells (EC50 = 6.96 µM) and inhibits LPS-induced nitric oxide production in RAW 264.7 cells (IC50 = 7.89 µM).{45354}

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