Pimodivir

Pimodivir

CAT N°: 29321
Price:

From 140.00 119.00

Pimodivir is an inhibitor of influenza virus polymerase basic protein 2 (PB2; KD = i = ~1.6 µM) and inhibits the activity of Axl and calcium/calmodulin-dependent protein kinase II? (CaMKII?) by greater than 50% in a panel of 65 human and rat kinases. Pimodivir decreases the replication of seven adamantine- and neuraminidase inhibitor-resistant strains of influenza virus A (EC50s = 16070), zanamivir (Item No. 15123), and favipiravir (T-705; Item No. 23384) with 50% combination index (CI50) values of 0.58, 0.64, and 0.89, respectively, in a cell-based assay.{52123} Pimodivir increases survival in a mouse model of intranasal influenza A infection when administered at doses of 1, 3, and 10 mg/kg twice per day.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (2S,3S)-3-[[5-fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-pyrimidinyl]amino]-bicyclo[2.2.2]octane-2-carboxylic acid
  • Correlated keywords
    • PB-2 flu anti viral T705 intra nasal GSK3beta intra nasal VX787 63623872ZCD 872 JNJ63623872 JNJ63623872ZCD JNJ872
  • Product Overview:
    Pimodivir is an inhibitor of influenza virus polymerase basic protein 2 (PB2; KD = i = ~1.6 µM) and inhibits the activity of Axl and calcium/calmodulin-dependent protein kinase II? (CaMKII?) by greater than 50% in a panel of 65 human and rat kinases. Pimodivir decreases the replication of seven adamantine- and neuraminidase inhibitor-resistant strains of influenza virus A (EC50s = 16070), zanamivir (Item No. 15123), and favipiravir (T-705; Item No. 23384) with 50% combination index (CI50) values of 0.58, 0.64, and 0.89, respectively, in a cell-based assay.{52123} Pimodivir increases survival in a mouse model of intranasal influenza A infection when administered at doses of 1, 3, and 10 mg/kg twice per day.

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