PIK-<wbr/>90

PIK-90

CAT N°: 10010749
Price:

From 28.00 23.80

PIK-90 is a potent and cell permeable phosphoinositide 3-kinase (PI3K) inhibitor (IC50 = 11, 350, 18, and 58 nM for p110 subunit isoforms ?, ?, ?, and ?, respectively).{21846} Through this action, PIK-90 reduces chemotaxis and induces apoptosis in chronic lymphocytic leukemia B cells.{21846} It also blocks proliferation of glioma cells in vitro.{14311} By inhibiting P110?, PIK-90 blocks insulin-stimulated phosphorylation of Akt in L1 adipocytes and L6 myotubes, preventing activation of the mTORC1 pathway.{14312}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-(2,3-dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide
  • Correlated keywords
    • 1029940-40-6 1206911-27-4 PIK-85 PIK85 cells signaling inhibitors signal transduction mTOR Akt cancers insulin diabetes PIK90 PIK 90 PI3K phosphoinositide 3-kinase kinases inhibits inhibitions chemotaxis apoptosis chronic lymphocytic leukemia B B-cells glioma L1 L6 myotubes
  • Product Overview:
    PIK-90 is a potent and cell permeable phosphoinositide 3-kinase (PI3K) inhibitor (IC50 = 11, 350, 18, and 58 nM for p110 subunit isoforms ?, ?, ?, and ?, respectively).{21846} Through this action, PIK-90 reduces chemotaxis and induces apoptosis in chronic lymphocytic leukemia B cells.{21846} It also blocks proliferation of glioma cells in vitro.{14311} By inhibiting P110?, PIK-90 blocks insulin-stimulated phosphorylation of Akt in L1 adipocytes and L6 myotubes, preventing activation of the mTORC1 pathway.{14312}

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