Phlorizin

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • 1-[2-(?-D-glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone
• Correlated keywords
  • Phloretin 2′-O-glucoside 2′-O-?-D-glucopyranoside 2′-glucoside 2′-?-D-Glucoside Phlorhizin Phloridzin Phloridzosid Phlorizine Phlorizoside Phlorrhizin 16055-86-0 52276-56-9 112318-65-7 sodium Na+ glucose co-transporters cotransporters transport 1 2 SGLT1 SGLT2 small intestines intestinal kidneys nephrons glomerulus Bowman’s capsules reabsorption blood streams inhibition inhibits inhibitors plasma levels diabetes treatments diabetic apple trees bark blocks blocking renal absorption ?-methyl-D-glucopyranoside ?-MDG uptake humans COS-1 cells expressing expression hSGLT1 hSGLT2 competitive glucosuria resorption Na+/D-glucose
• Product Overview:
  Sodium-glucose cotransporter 1 (SGLT1) is a high affinity, low capacity transporter abundant in the small intestine, with some expression in the kidney as well. SGLT2 is a low affinity, high capacity transporter in the kidney that accounts for approximately 90% of glucose reabsorption into the blood stream. Selective inhibition of SGLT2 is a potential strategy for reducing plasma glucose levels as a treatment for diabetes.{20896} Phlorizin is a natural product, first isolated from the bark of apple trees, that reduces plasma glucose levels by blocking renal and intestinal glucose absorption through inhibition of SGLT1 and SGLT2.{20893,20892} It competitively inhibits the initial rate of ?-methyl-D-glucopyranoside (?-MDG) uptake in human COS-1 cells expressing hSGLT1 and hSGLT2 with IC50 values of 400 and 65 nM, respectively.{20895} In HEK293T cells expressing human SGLT1 and SGLT2, phlorizin exhibits Ki values of 140 and 11 nM, respectively, at 37°C.{20895,20894}