Philantho<wbr/>toxin 74 (hydro<wbr>chloride)

Philanthotoxin 74 (hydrochloride)

CAT N°: 14607
Price:

From 102.00 86.70

Philanthotoxin 74 (PhTx-74) is a synthetic analog of the naturally-occurring wasp venom toxin philanthotoxin-4,3,3. It is a subtype-selective AMPA receptor antagonist that inhibits homomeric GluR1 and GluR3 as well as heteromeric GluR1/2 receptors (80-100% of glutamate-evoked currents inhibited at 100 µM). It exhibits minimal to no effect on monomeric GluR2 or heteromeric GluR2/3 receptors at concentrations up to 500 µM.{23500} PhTx-74 inhibits the GluR5(Q) receptor with a Ki value of 0.29 µM.{23501}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-[7-[(4-aminobutyl)amino]heptyl]-4-hydroxy-?S-[(1-oxobutyl)amino]-benzenepropanamide, dihydrochloride
  • Correlated keywords
    • 401601-12-5 toxins PhTx-74 PhTx74 glutamates receptors AMPA GluR1 GluR2 GluR1/2 GluR2/3 GluR5(Q) AMPA PhTx74 PhTX 74 analogs natural naturally wasps venom homomeric inhibits inhibitions inhibitors synthetics hydrochloride HCl philanthotoxin-74 GluRs GluR-1 GluR-2 GluR-1/2 GluR-2/3 GluR-5 1 2 5 ½ 2/3 neuroscience signals transductions receptors antagonists monomeric heteromeric
  • Product Overview:
    Philanthotoxin 74 (PhTx-74) is a synthetic analog of the naturally-occurring wasp venom toxin philanthotoxin-4,3,3. It is a subtype-selective AMPA receptor antagonist that inhibits homomeric GluR1 and GluR3 as well as heteromeric GluR1/2 receptors (80-100% of glutamate-evoked currents inhibited at 100 µM). It exhibits minimal to no effect on monomeric GluR2 or heteromeric GluR2/3 receptors at concentrations up to 500 µM.{23500} PhTx-74 inhibits the GluR5(Q) receptor with a Ki value of 0.29 µM.{23501}

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