PG-01037 (hydro<wbr/>chloride)

PG-01037 (hydrochloride)

CAT N°: 22079
Price:

From 48.00 40.80

PG-01037 is a selective dopamine D3 receptor antagonist (Kis = 0.7, 93, and 375 nM for HEK293 cells expressing human D3, D2, and D4 receptors, respectively).{34174} It inhibits quinpirole-induced stimulation of mitogenesis in CHO cells expressing human dopamine D3 receptors (EC50 = 3 nM). PG-01037 (32 mg/kg) reduces progressive-ratio methamphetamine self-administration in rats allowed extended access.{36955} It reduces loss of dopaminergic neurons in the substantia nigra pars compacta and improves motor performance in the coat-hanger test in a mouse model of Parkinson’s disease induced by MPTP.{36956}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-[(2E)-4-[4-(2,3-dichlorophenyl)-1-piperazinyl]-2-buten-1-yl]-4-(2-pyridinyl)-benzamide, dihydrochloride
  • Correlated keywords
    • 790658-27-4 PG01037 D-3 2 4 HEK-293 Chinese hamster ovary 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Product Overview:
    PG-01037 is a selective dopamine D3 receptor antagonist (Kis = 0.7, 93, and 375 nM for HEK293 cells expressing human D3, D2, and D4 receptors, respectively).{34174} It inhibits quinpirole-induced stimulation of mitogenesis in CHO cells expressing human dopamine D3 receptors (EC50 = 3 nM). PG-01037 (32 mg/kg) reduces progressive-ratio methamphetamine self-administration in rats allowed extended access.{36955} It reduces loss of dopaminergic neurons in the substantia nigra pars compacta and improves motor performance in the coat-hanger test in a mouse model of Parkinson’s disease induced by MPTP.{36956}

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