PF-4800567

PF-4800567

CAT N°: 19171
Price:

From 55.00 46.75

PF-4800567 is a selective inhibitor of casein kinase 1? (CK1?; IC50 = 32 nM) with greater than 20-fold selectivity over CK1?.{30939} It blocks CK1?-mediated PER3 nuclear localization and PER2 degradation, both of which are proteins important for maintaining circadian rhythms in cells.{30939} PF-4800567 has been used in the study of the CK1 enzymes in the regulation of circadian rhythm and is also reported to have neuroprotective effects.{30939,30937,30938}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3-[(3-chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
  • Correlated keywords
    • casein kinase 1? 1E CK1? CK1E PER-2 PER-3 PF4800567 CK-1? CK-1E
  • Product Overview:
    PF-4800567 is a selective inhibitor of casein kinase 1? (CK1?; IC50 = 32 nM) with greater than 20-fold selectivity over CK1?.{30939} It blocks CK1?-mediated PER3 nuclear localization and PER2 degradation, both of which are proteins important for maintaining circadian rhythms in cells.{30939} PF-4800567 has been used in the study of the CK1 enzymes in the regulation of circadian rhythm and is also reported to have neuroprotective effects.{30939,30937,30938}

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